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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP4E1
All Species:
16.67
Human Site:
S545
Identified Species:
40.74
UniProt:
Q9UPM8
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPM8
NP_031373.2
1137
127287
S545
Y
K
L
L
M
N
D
S
V
S
S
E
T
K
A
Chimpanzee
Pan troglodytes
XP_001169245
1137
127426
S545
Y
K
L
L
M
N
D
S
V
S
S
E
T
K
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535479
1138
127884
S545
Y
K
L
L
M
N
D
S
V
S
S
E
T
K
A
Cat
Felis silvestris
Mouse
Mus musculus
Q80V94
1122
124787
S544
Y
K
L
L
M
S
D
S
I
S
S
E
T
K
A
Rat
Rattus norvegicus
P18484
938
104026
I369
H
E
A
V
K
T
H
I
E
T
V
I
N
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_699042
1121
123888
S538
M
K
L
L
E
Q
K
S
V
S
S
E
T
R
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91926
940
105602
E371
E
E
V
K
K
H
Q
E
V
V
I
L
S
M
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328755
980
107167
D411
D
Y
M
I
S
I
N
D
N
H
Y
K
T
E
I
Maize
Zea mays
NP_001169710
969
105519
D400
T
N
V
E
V
I
V
D
R
M
I
E
Y
M
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12028
832
93606
C263
G
Y
D
V
Q
G
I
C
D
P
F
L
Q
C
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
91.7
N.A.
79.9
20.7
N.A.
N.A.
N.A.
N.A.
54.1
N.A.
21.5
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
N.A.
95.5
N.A.
87.6
41.1
N.A.
N.A.
N.A.
N.A.
71.6
N.A.
42.2
N.A.
N.A.
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
86.6
0
N.A.
N.A.
N.A.
N.A.
60
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
31.4
30.4
N.A.
N.A.
20.9
N.A.
Protein Similarity:
49
48.7
N.A.
N.A.
38.6
N.A.
P-Site Identity:
6.6
6.6
N.A.
N.A.
0
N.A.
P-Site Similarity:
40
20
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
0
0
0
10
40
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
0
0
10
0
% C
% Asp:
10
0
10
0
0
0
40
20
10
0
0
0
0
0
0
% D
% Glu:
10
20
0
10
10
0
0
10
10
0
0
60
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% G
% His:
10
0
0
0
0
10
10
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
20
10
10
10
0
20
10
0
0
20
% I
% Lys:
0
50
0
10
20
0
10
0
0
0
0
10
0
40
10
% K
% Leu:
0
0
50
50
0
0
0
0
0
0
0
20
0
0
10
% L
% Met:
10
0
10
0
40
0
0
0
0
10
0
0
0
20
0
% M
% Asn:
0
10
0
0
0
30
10
0
10
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
10
10
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
10
10
0
50
0
50
50
0
10
0
0
% S
% Thr:
10
0
0
0
0
10
0
0
0
10
0
0
60
0
0
% T
% Val:
0
0
20
20
10
0
10
0
50
10
10
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
40
20
0
0
0
0
0
0
0
0
10
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _